Antitumor vaccine of Ukrainian production: an affordable method of cancer therapy

The cancer autovaccine is one of the new possibilities of modern immunology. It is aimed at increasing the ability of human dendritic cells to recognize tumor cells as pathological formations and destroy them.

Dendritic cells are a type of white blood cell. They recognize foreign cells (viral, bacterial, toxins) and transmit information about their appearance to T-lymphocytes. After that, the process of inflammation begins, aimed at destroying genetically different cells.

Dendritic cells act in about the same way in relation to the tissues of their body if a defect or mutation appears in them. This process is much more complicated, because in this case, abnormal cells remain part of the body, that is, they do not have genetic differences. Modern science still does not know by what characteristics dendritic cells recognize malignant cells as subject to destruction.

The latest generations of immunological preparations are aimed at increasing the recognition of tumor cells by the immune system.

Types of immunological drugs

Targeted immunological drugs

For some types of tumors, mutations are known, in the presence of which the immune system works worse than usual.For such situations, drugs have been developed that target this particular mutation. They are effective for some forms of cancer of the internal organs.

Virus-based immune drugs

For other types of malignant tumors, such as leukemia, there are special viruses that can destroy altered cells.

Non-specific immunological vaccines

BCG vaccine recently introduced into clinical protocols. As a vaccine against tuberculosis, it is used only in the post-Soviet space, and as a drug effective against bladder cancer, BCG is included in the NCCN, America’s main clinical oncological protocol.

Autologous vaccine (Cancerax active)

The leading immunological therapy option is the autologous vaccine. Cancerax active is a customized cancer vaccine that is developed based on the patient’s tumor and immune cells.

To do this, take a biopsy from the tumor.Also, venous blood is taken, the necessary cells are isolated from it.Blood components are mixed with tumor tissue, an extract is prepared from this product, which is then injected into the patient’s body.

Dendritic cells produce a large number of antibodies against tumor tissue, and when antibodies enter the patient’s body, new antibodies, firstly, destroy the tumor itself, and secondly, they serve as a source of information for other immune cells.Thus, the body begins to better fight malignant formation.

This vaccine was developed at the National Institute of Experimental Pathology, Radiobiology and Oncology named after E. Kavetskiy, Ukraine.Cancerax active is selected individually for each patient, provided that the correct biopsy of the tumor material is performed.

The prototype for such a vaccine was Coli’s vaccine.It was developed on the principle of mixing tumor tissue with bacterial cells.

Now there are 2 such vaccines in the world – a Japanese vaccine and an autologous vaccine developed at the Institute of Experimental Pathology, Radiobiology and Oncology E. Kavetsky, Ukraine.For patients from the CIS countries and Europe, taking into account the need to inject several times, the Ukrainian antitumor vaccine is more accessible.

How works Cancerax active cancer vaccine works

The best treatment results are obtained when the vaccine is given shortly after surgery.In this case, the results of overall and disease-free survival are increased up to 2 times compared with standard indicators.For the full course of treatment, 3-5 injections are required.

Vaccination is contraindicated in the terminal stages of the disease and malignant blood formations – in this case, the activation of one’s own immunity is not always safe.

Features of the use of the cancer vaccine Cancerax active

The vaccine should be used 10-14 days after abdominal surgery and 3-5 days after minimally invasive surgery.Therefore, patients together with doctors should carefully plan treatment so as not to start the course of injections on time and not to reduce its effectiveness.

It is necessary to undergo surgical treatment by a qualified surgeon who can correctly collect material for the manufacture of a future vaccine.

Restrictions on the use of autovaccines

The cancer vaccine Cancerax active has passed all stages of clinical trials in lung and ovarian cancer has shown good results in the treatment of breast, gastrointestinal and intestinal cancers. But it is not used to treat other cancers such as sarcomas (malignant tumors of the connective tissue), and is contraindicated in malignant tumors of the blood system.The activation of immunity in leukemia or lymphoma can lead to the spread of the tumor process.

The safety of using an antitumor vaccine

Cancerax active has been recommended for use by the Ministry of Health of Ukraine since 2003.During this time, convincing data on its effectiveness have been obtained. Thus, the deputy director of the National Cancer Institute, Lukashenko, believes that vaccination carried out immediately after surgical treatment improves the results of oncological treatment up to 2 times.The vaccine has been proven to be safe.Since it is developed on the basis of the patient’s own material, there are no contraindications to its use, and the shelf life is limited by a possible increase in temperature in the first 72 hours after administration.

Availability of Ukrainian cancer vaccine

Cancerax active vaccine is a Ukrainian development.Registration and re-registration procedures in Ukraine are relatively inexpensive compared to EU countries, which significantly reduces the cost of developing a vaccine and makes it more affordable for patients. In addition, the Ukrainian legislation does not have very complicated procedures for admitting foreign patients, which also contributes to an increase in the availability of treatment.

If you would like to take cancer therapy with the active Cancerax auto vaccine, please leave it on the MedTour website. The coordinating doctor will consult you free of charge and organize treatment in Ukraine

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Published: 06.01.2022

Updated: 06.01.2022

Medical expert:

PhD. Olexandr Voznyak

Medical author, Medical expert:

Kateryna Maliarchuk