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Osteomyelofibrosis treatment
Osteomyelofibrosis is a disease that is based on the growth of connective tissue in the bone marrow, which causes a violation of the normal functioning of the organ.
Osteomyelofibrosis can be
- Primary,
- Secondary, most often develops after true polycythemia and essential thrombocytemia
Average survival rate
- Approximately 5 years,
For some patients over 55 years of age, the disease is not fatal, subject to monitoring, does not lead to mortality, - In 20% of patients, the disease is transformed into acute leukemia, and then survival depends on the success of treatment of leukemia
MedTour patients recommend clinics for the treatment of osteomyelofibrosis:
Republic of Korea, Seoul
Samsung Medical Center
5.00
Excellent(1 review)
Admission fee:
from 100 USD
Turkey, Istanbul
Medipol University Hospital
5.00
Excellent(1 review)
Admission fee:
from 120 USD
Israel, Tel-Aviv
Sourasky Medical Center (Ichilov Clinic)
5.00
Excellent(1 review)
Admission fee:
from 600 USD
Turkey, Istanbul
LIV Hospitals
5.00
Excellent(1 review)
Admission fee:
from 120 USD
Turkey, Istanbul
Medical Park Hospitals Network
4.67
Excellent(6 reviews)
Admission fee:
from 130 USD
Turkey, Istanbul
Memorial Hospitals
4.22
Excellent(9 reviews)
Admission fee:
from 140 USD
Italy, Milan
San Raffaele Hospital
Admission fee:
from 300 USD
Germany, Hamburg
Hospital network «Asklepios»
Admission fee:
from 400 USD
Germany, Berlin
Helios Hospital Berlin-Buch
3.50
Good(2 reviews)
Admission fee:
from 280 USD
Spain, Barcelona
Quirónsalud Barcelona Hospital
Admission fee:
from 450 USD
Spain, Barcelona, Madrid
HM Hospitals
Admission fee:
from 300 USD
Turkey, Istanbul
Hisar Hospital Intercontinental
Admission fee:
from 120 USD
Republic of Korea, Seoul
Seoul National University Hospital (SNUH)
Admission fee:
from 50 USD
Czech Republic, Prague
Motol University Hospital
3.00
Good(1 review)
Admission fee:
To be clarified
Germany, Krefeld (Dusseldorf)
Helios Krefeld clinic
4.00
Excellent(1 review)
Admission fee:
from 600 USD
Spain, Barcelona
Sant Joan de Déu Children’s Hospital
Admission fee:
To be clarified
Turkey, Istanbul
Okan University Hospital
Admission fee:
To be clarified
Turkey, Istanbul
Anadolu Medical Center
4.10
Excellent(10 reviews)
Admission fee:
from 120 USD
Israel, Jerusalem
Hadassah Medical Center
5.00
Excellent(1 review)
Admission fee:
from 700 USD
Israel, Ramat Gan
Sheba Medical Center
4.67
Excellent(3 reviews)
Admission fee:
from 600 USD
20 clinics of 33
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Doctors for the treatment of osteomyelofibrosis
Frequently Asked Questions
what are the symptoms of osteomyelofibrosis
- Weakness,
- Bleeding and long-term wound healing,
- Left abdominal pain and enlarged spleen,
- Decreased vision,
- Decreased appetite,
- The appearance of fluid in the abdominal cavity,
- Edema of the lower extremities,
- Changes in the blood test
What are the complications of osteomilofibrosis
- Kidney stone disease,
- Pyelonephritis,
- Nephrosclerosis,
- Gout,
- Bleeding,
- Development of acute myeloid leukemia
Why do patients often choose osteomyelofibrosis treatment abroad
- This is a very rare pathology, occurs in approximately 1: 100,000 people. Therefore, it is better to treat it in specialized centers, since most doctors (both diagnosticians and clinicians) do not have clinical experience in the treatment of osteomyelofibrosis.
- The success rate of bone marrow transplantation in the hematology departments of Turkey, Germany, Israel and Spain is ten times higher than in the CIS.
- If additional methods of treatment are required, techniques are used that are not available in the domestic space — operations on the Da Vinci robot, which is much less traumatic than open and laparoscopic surgical interventions, proton therapy as a more effective and safe alternative to radiation therapy, and so on.
Methods of diagnosis and treatment of osteomyelofibrosis according to the world standards of 2021
How to diagnose osteomyelofibrosis
- The first diagnostic procedure is a general blood test, which most often
determines changes in the number of red blood cells and platelets. - Then a trepanobiopsy is performed (this is a type of biopsy in which a column ofcells is taken from the desired area, after which it is prepared accordingly andexamined under a microscope) of the bone marrow with molecular and cytogenetic studies of the material taken. V617F mutations of the JAK2 (in ≈60 %), CALR (in 25-35%), and MPL(in 4-8%) genes are studied.
Instead of a diagnosis of «osteomyelofibrosis», they may be mistakenly diagnosed with
- Acute leukemia,
- Multiple myeloma,
- Hodgkin`s disease,
- Chronic benzene poisoning
What are the modern methods of treatment of osteomyelofibrosis in modern
foreign clinics
- The only option in which the patient can achieve a complete cure is
allotransplantation (transplantation from a donor) of bone marrow. - As auxiliary methods, experienced doctors use the targeted drug ruxolitinib, as well as hydroxyurea, melfan, busulfan, cladribine or human interferon, sometimes they also perform splenectomy.
Also, in parallel with the main treatment, doctors conduct symptomatic treatment of anemia, pain syndrome, thrombocytopenia and other possible complications. - Some patients can be left under observation without special treatment. Health assessment is carried out using special scales for patients with low — risk osteomilofibrosis-IPSS, DIPSS or DIPSS plus.
Published:
Updated:
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